Variations in active outflow along the trabecular outflow pathway
نویسندگان
چکیده
منابع مشابه
Trabecular meshwork and outflow
Core Concepts • iOP elevation results from increased outflow resistance in the outflow pathways: the trabecular meshwork (TM) and the uveoscleral pathway. • steady-state iOP is found in normal eyes where iOP builds up in response to inflow of aqueous humour to the level sufficient to drive fluid across the resistance of the outflow pathways. • in most glaucomatous eyes, the resistance of the ou...
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PURPOSE To determine the relative contributions to aqueous outflow resistance of the tissues distal to the inner wall of Schlemm's canal. METHODS While performing constant pressure perfusion at 10 mm Hg, a 193-nm excimer laser (Questek) was used to precisely remove portions of sclera, unroofing Schlemm's canal while leaving the inner wall intact. The laser beam was masked to produce a beam 2 ...
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PURPOSE The structures of the ocular anterior segment responsible for aqueous humor secretion and absorption have been well characterized in mammals. However, the underlying molecular and cellular mechanisms that regulate aqueous humor flow have remained elusive. Experimental analysis in Danio rerio, the zebrafish, is providing mechanistic insights into many cellular processes relevant to norma...
متن کاملAqueous outflow - A continuum from trabecular meshwork to episcleral veins
In glaucoma, lowered intraocular pressure (IOP) confers neuroprotection. Elevated IOP characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased resistance in the trabecular meshwork (TM), a filter-like structure essential to regulate AH outflow, may result in the impaired outflow. Flow through the 360° circumference of TM structures may be non-uniform, divided into h...
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BACKGROUND The intraocular pressure (IOP) is maintained through a dynamic equilibrium between the production and drainage of aqueous humor. Elevation of intraocular pressure is mainly caused by the blocking of aqueous humor outflow pathway. Therefore, it is particularly important to study the structure of drainage pathway and the effect of ocular hypertension at the process of aqueous humor out...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2016
ISSN: 0014-4835
DOI: 10.1016/j.exer.2016.01.008